In a double-blind trial from Japan in 158 patients with rheumatoid arthritis comparing two nonsteroidal, anti-inflammatory drugs (NSAIDs), tolfenamic acid and indomethacin, 857 significance tests were reported.1 There were analyses of baseline data, multiple benefits and harms outcomes, subgroup analyses based on patient characteristics, control visits, etc. World record in number of P-values

These drugs are analgesics, but doctors falsely believe that they also have an anti-inflammatory effect. They very often use them in combination with paracetamol because of this belief, even when randomised trials have failed to find an additional effect of the combination compared to using paracetamol alone. I have explained in two of my books

In our one-year study we found that advertised drugs were 6 times more expensive than comparators but not better. Our study may have been the reason why the Journal of the Danish Medical Association decided to no longer publish drug ads. Other journals should follow suit.

On 1 February 2011, we got access to the clinical study reports and their corresponding protocols of placebo controlled trials of two slimming pills, rimonabant and orlistat, submitted by the manufacturers to the European Medicines Agency (EMA) for obtaining marketing approval in the European Union. We applied for access in June 2007, but EMA did

It is highly likely that SARS-CoV-2, the coronavirus that caused the COVID-19 pandemic, escaped from the Wuhan Institute of Virology because of sloppy safety procedures. It is also likely that the virus was fabricated on purpose to make it dangerous to humans as part of the so-called gain-of-function research at the institute. Read more

I describe what is likely the beginning to the end for Cochrane. According to its major funder, the writing has been on the wall for 8 years, which is exactly the period when Cochrane’s new CEO, journalist Mark Wilson, ruled the organisation and destroyed it. He suddenly left his job, in the middle of a

At a meeting about COVID-19, Sharav talked endlessly about Nazi atrocities. Much of what she said was pure speculation or constituted totally unjustified parallels to current day societies. Sharav considers Andrew Wakefield, one of the biggest fraudsters in medicine, a hero, and as she is believed by corona deniers to be a credible witness for

(Rapid response to a BMJ article, reproduced here) 08 April 2021 Maryanne Demasi, Researcher, journalist and Prof Peter Gøtzsche, Institute for Scientific Freedom, Copenhagen 2970, Denmark @MaryanneDemasi Dear Editor The conversation about COVID-19 vaccine passports has reached fever pitch, with many media outlets reporting that proof of vaccination may be required for entry into pubs,

An “anti-vaxxer” group of people, United Health Professionals, has sent a totally misleading letter to the governments in 30 countries. Peter Gøtzsche has highlighted the many falsehoods and nonsense statements in their letter. Open letter to President Jair Bolsonaro

We submitted our review to four different journals that all accept systematic reviews of animal research, but ended up publishing the review on our website.